LOS ANGELES?American actress Sigourney Weaver is going to play the queen of the vampires in the horror comedy "Vamps," trade magazine The Hollywood Reporter said Wednesday.

Written and directed by Amy Heckerling ("Look Who's Talking," "Clueless"), this comedy follows two vampirettes (Alicia Silverstone and Krysten Ritter) through the New York club scene where they fall in love with human boys, putting at risk their immortality.

Weaver, 60, will play the part of Ciccerus, the blood thirsty queen of the vampires, who is responsible for the young heroines' transformation into creatures of the night. Filming is supposed to begin in April.

Recently seen in "Avatar", James Cameron's film phenomenon, Weaver won fame in the role of Ellen Ripley in the chilling "Alien" series. She received an Oscar nomination in 1986 for the second film in the series, which was directed by Cameron.

In 1988, she was nominated for two Oscars, for best actress in "Gorillas in the Mist" and for best supporting actress for "Working Girl."